ChloroquineV1, Main, Exploration, bibRecord, 003083

Chloroquine poisoning in a child

Identifieur interne : 003083 ( Main/Exploration ); précédent : 003082; suivant : 003084

Chloroquine poisoning in a child

Auteurs : James C. Kelly [États-Unis] ; Gary S. Wasserman [États-Unis] ; Walter D. Bernard [États-Unis] ; Christopher Schultz [États-Unis] ; Jane F. Knapp

Source :

Annals of Emergency Medicine [ 0196-0644 ] ; 1990.

RBID : ISTEX:E3249AACF8D2D962C010D3718C2D6320282AA581

English descriptors

KwdEn :
- chloroquine, ingestion.
Teeft :
- Chloroquine, Chloroquine base, Chloroquine poisoning, Chloroquine tablets, Emergency medicine, First hospital, Gastrointestinal absorption, Ingestion, Mercy hospital, Narrow margin, Outlying hospital, Pediatric, Pediatric emergency medicine, Peritoneal dialysis, Poisoning, Publication september, Second hospital, Serum level, Severe engl, Tablet, Ventricular bradycardia.

Abstract

Chloroquine poisoning in children, although infrequent, is extremely dangerous because of the narrow margin between therapeutic and toxic doses. Children clinically present with apnea, seizures, and cardiac arrhythmias. We present the case of a 12-month-old infant, the second-youngest patient reported in the US literature to die from chloroquine poisoning. A serum level of 4.4 mg/L (13.64 μmol/L) was obtained after the infant ingested only one tablet (300 mg). This establishes a new minimal lethal dose/blood level for children. Although some pediatric and adult pharmacokinetic and clinical similarities exist, the outcome is different. Pediatric mortality is 80%, whereas adult mortality is only 10%. Pediatric ingestion cases are primarily unintentional, and most adult cases are suicide attempts. Current treatment in adults includes a protocol of diazepam and epinephrine. Further studies involving children and these medications and other modalities are needed to improve survival.

Url:

https://api.istex.fr/ark:/67375/6H6-CZBZS1P5-9/fulltext.pdf

DOI: 10.1016/S0196-0644(05)82141-9

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000766
to stream Istex, to step Curation: 000766
to stream Istex, to step Checkpoint: 001E54
to stream Main, to step Merge: 003152
to stream Main, to step Curation: 003083

Le document en format XML

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<term>Publication september</term>
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<front><div type="abstract" xml:lang="en">Chloroquine poisoning in children, although infrequent, is extremely dangerous because of the narrow margin between therapeutic and toxic doses. Children clinically present with apnea, seizures, and cardiac arrhythmias. We present the case of a 12-month-old infant, the second-youngest patient reported in the US literature to die from chloroquine poisoning. A serum level of 4.4 mg/L (13.64 μmol/L) was obtained after the infant ingested only one tablet (300 mg). This establishes a new minimal lethal dose/blood level for children. Although some pediatric and adult pharmacokinetic and clinical similarities exist, the outcome is different. Pediatric mortality is 80%, whereas adult mortality is only 10%. Pediatric ingestion cases are primarily unintentional, and most adult cases are suicide attempts. Current treatment in adults includes a protocol of diazepam and epinephrine. Further studies involving children and these medications and other modalities are needed to improve survival.</div>
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Serveur d'exploration Chloroquine

Chloroquine poisoning in a child

Chloroquine poisoning in a child

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri